Overview

Location [1]
1q42.13
Protein [2]
Histone H3.1t
Synonyms [1]
H3/g, H3t, H3FT, H3.4

HIST3H3 is altered in 0.73% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

HIST3H3 GENIE Cases - Top Diseases

The most common alterations in HIST3H3 are HIST3H3 Amplification (0.29%), HIST3H3 Loss (0.05%), HIST3H3 R3Q (0.02%), HIST3H3 R50C (0.02%), and HIST3H3 E98K (0.01%) [3].

HIST3H3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.