Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
12q14.3
Protein [2]
High mobility group protein HMGI-C
Synonyms [1]
HMGIC, LIPO, BABL, HMGI-C, STQTL9

High mobility group AT-hook 2 (HMGA2) is a gene that encodes a protein that functions as an architectural factor and a component of the enhancesome. The protein may also be a transcriptional regulator. Fusions, missense mutations, silent mutations, and nonstop extensions are observed in cancers such as breast cancer, liver cancer, and lung cancer.

HMGA2 is altered in 0.06% of all cancers.

Significance of HMGA2 in Diseases

Breast Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.