Overview

High mobility group AT-hook 2 (HMGA2) is a gene that encodes a protein that functions as an architectural factor and a component of the enhancesome. The protein may also be a transcriptional regulator. Fusions, missense mutations, silent mutations, and nonstop extensions are observed in cancers such as breast cancer, liver cancer, and lung cancer.

Significance of HMGA2 in Diseases

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.