Location [1]
Protein [2]
Protein Hook homolog 3
Synonyms [1]

Hook microtubule-tethering protein 3 (HOOK3) is a gene that encodes a protein that mediate binding between microtubules and organelles. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as small intestine cancer, stomach cancer, and colon cancer.

HOOK3 is altered in 0.10% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, bladder urothelial carcinoma, and colorectal adenocarcinoma having the greatest prevalence of alterations [3].

HOOK3 GENIE Cases - Top Diseases

The most common alterations in HOOK3 are HOOK3-RET Fusion (0.10%), HOOK3 E648Q (0.77%), HOOK3 *719Y (0.39%), HOOK3 A240T (0.39%), and HOOK3 A456V (0.22%) [3].

HOOK3 GENIE Cases - Top Alterations

Significance of HOOK3 in Diseases

Thyroid Gland Papillary Carcinoma +

Malignant Solid Tumor +

Histiocytosis +

Lymphoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.