Overview

Location [1]
8p11.21
Synonyms [1]
HK3

Hook microtubule-tethering protein 3 (HOOK3) is a gene that encodes a protein that mediate binding between microtubules and organelles. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as small intestine cancer, stomach cancer, and colon cancer.

Significance of HOOK3 in Diseases

Histiocytosis +

Lymphoma +

Malignant Solid Tumor +

Poorly Differentiated Thyroid Gland Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Papillary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.