Overview

Location [1]
17q21.32
Protein [2]
Homeobox protein Hox-B13
Synonyms [1]
PSGD, HPC9

Homeobox B13 (HOXB13) is a gene that encodes a protein that functions as a transcription factor in the homeobox family. Missense mutations, silent mutations, nonsense mutations, and insertion frameshifts are observed in cancers such as skin cancer, stomach cancer, and endometrial cancer.

HOXB13 is altered in 1.01% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, invasive breast carcinoma, prostate adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

HOXB13 GENIE Cases - Top Diseases

The most common alterations in HOXB13 are HOXB13 Amplification (0.46%), HOXB13 Loss (0.02%), HOXB13 A212T (0.01%), HOXB13 R247C (0.01%), and HOXB13 X201_splice (0.02%) [3].

HOXB13 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.