Biomarkers /
HSP90AB1
Overview
Heat shock protein 90 kDa alpha (cytosolic), class B member 1 (HSP90AB1) is a gene that encodes a protein that functions in signal transduction, protein folding, protein degradation, and morphological evolution. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
HSP90AB1 is altered in 0.94% of all cancers with conventional glioblastoma multiforme, colorectal adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, and skin squamous cell carcinoma having the greatest prevalence of alterations [3].
The most common alterations in HSP90AB1 are HSP90AB1 Mutation (0.91%), HSP90AB1 C589R (0.22%), HSP90AB1 D151N (0.09%), HSP90AB1 D152del (0.20%), and HSP90AB1 D264N (0.07%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.