Overview

Location [1]
1p36.12
Protein [2]
DNA-binding protein inhibitor ID-3
Synonyms [1]
HEIR-1, bHLHb25

Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein (ID3) is a gene that encodes a protein that functions in the inhibition of the DNA binding of any helix-loop-helix protein with which it interacts. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions and insertions are observed in cancers such as hematopoietic and lymphoid cancers, liver cancer, and lung cancer.

ID3 is altered in 0.43% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, diffuse large B-cell lymphoma, not otherwise specified, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

ID3 GENIE Cases - Top Diseases

The most common alterations in ID3 are ID3 Mutation (0.22%), ID3 Loss (0.17%), ID3 Amplification (0.05%), ID3 S49T (0.04%), and ID3 L64F (0.03%) [3].

ID3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.