Biomarkers /

IFNGR1

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Associated Diseases

Overview

Location [1]
6q23.3
Protein [2]
Interferon gamma receptor 1
Synonyms [1]
IMD27A, IFNGR, CD119, IMD27B

IFNGR1 is altered in 0.87% of all cancers with breast invasive ductal carcinoma, dedifferentiated liposarcoma, lung adenocarcinoma, colon adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

IFNGR1 GENIE Cases - Top Diseases

The most common alterations in IFNGR1 are IFNGR1 Amplification (0.22%), IFNGR1 Loss (0.11%), IFNGR1 S306* (0.01%), IFNGR1 E110* (0.01%), and IFNGR1 E218del (0.01%) [3].

IFNGR1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.