Location [1]
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Insulin-like growth factor 1 receptor beta chain
Synonyms [1]

Insulin-like growth factor 1 receptor (IGF1R) is a gene that encodes a protein that is a receptor tyrosine kinase that binds insulin-like growth factor. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

IGF1R is altered in 2.28% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

IGF1R GENIE Cases - Top Diseases

The most common alterations in IGF1R are IGF1R Mutation (2.19%), IGF1R Amplification (0.44%), IGF1R Loss (0.05%), IGF1R R1246C (0.02%), and IGF1R G693S (0.02%) [3].

IGF1R GENIE Cases - Top Alterations

Significance of IGF1R in Diseases

Cancer +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.