Location [1]
Protein [2]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Synonyms [1]

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE) is a gene that encodes a protein kinase that regulates antiviral signaling pathways. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

IKBKE is altered in 1.45% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

IKBKE GENIE Cases - Top Diseases

The most common alterations in IKBKE are IKBKE Mutation (0.86%), IKBKE Amplification (0.60%), IKBKE Loss (0.05%), IKBKE R127W (0.02%), and IKBKE R134H (0.02%) [3].

IKBKE GENIE Cases - Top Alterations

Significance of IKBKE in Diseases

Bladder Carcinoma +

Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.