IKAROS family zinc finger 3 (Aiolos) (IKZF3) is a gene that encodes a protein that functions as a hematopoietic-specific transcription factor that regulates lymphocyte development. Importantly, the protein is involved in the regulation of B lymphocyte proliferation and differentiation. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as biliary tract cancer, intestinal cancer, and skin cancer.
Modified: July 1, 2015
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