Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Type I inositol 3,4-bisphosphate 4-phosphatase
Synonyms [1]

INPP4A is altered in 1.32% of all cancers with lung adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

INPP4A GENIE Cases - Top Diseases

The most common alterations in INPP4A are INPP4A Mutation (1.10%), INPP4A Amplification (0.10%), INPP4A Loss (0.02%), INPP4A R938Q (0.02%), and INPP4A A753T (0.01%) [3].

INPP4A GENIE Cases - Top Alterations

Significance of INPP4A in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.