Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
4q31.21
Protein [2]
Type II inositol 3,4-bisphosphate 4-phosphatase
Synonyms [1]
-

Inositol polyphosphate-4-phosphatase, type II (INPP4B) is a gene that encodes a protein that functions as a dephosphorylating enzyme in the phosphatidylinositol signaling pathways. Missense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and lung cancer.

INPP4B is altered in 1.18% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

INPP4B GENIE Cases - Top Diseases

The most common alterations in INPP4B are INPP4B Mutation (0.75%), INPP4B Amplification (0.09%), INPP4B Loss (0.04%), INPP4B R818Efs*4 (0.02%), and INPP4B R252* (0.01%) [3].

INPP4B GENIE Cases - Top Alterations

Significance of INPP4B in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.