Overview

Location [1]
5q31.1
Protein [2]
Interferon regulatory factor 1
Synonyms [1]
MAR, IRF-1

Interferon regulatory factor 1 (IRF1) is a gene that encodes a protein that functions as a regulatory transcription factor that activates interferon alpha and beta transcription. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, stomach cancer, and urinary tract cancer.

IRF1 is altered in 0.16% of all cancers with acute myeloid leukemia, acute myeloid leukemia with myelodysplasia-related changes, diffuse large B-cell lymphoma, not otherwise specified, myelodysplastic syndromes, and myeloproliferative neoplasm having the greatest prevalence of alterations [3].

IRF1 GENIE Cases - Top Diseases

The most common alterations in IRF1 are IRF1 Loss (0.31%), IRF1 X285_splice (0.07%), IRF1 Amplification (0.02%), IRF1 R64* (0.02%), and IRF1 R82H (0.02%) [3].

IRF1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.