Overview

Location [1]
4q35.1
Protein [2]
Interferon regulatory factor 2
Synonyms [1]
IRF-2

Interferon regulatory factor 2 (IRF2) is a gene that encodes a transcription factor that inhibits activation of interferons alpha and beta and activates histone H4. Missense mutations, synonymous mutations, nonsense mutations, frameshift deletions, and inframe deletions are observed in cancers such as stomach cancer, colon cancer, and meningeal cancer.

IRF2 is altered in 0.64% of all cancers with colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, lung adenocarcinoma, and rectal adenocarcinoma having the greatest prevalence of alterations [3].

IRF2 GENIE Cases - Top Diseases

The most common alterations in IRF2 are IRF2 Loss (0.18%), IRF2 Amplification (0.12%), IRF2 R253W (0.12%), IRF2 R325W (0.19%), and IRF2-TMPRSS2 Fusion (0.09%) [3].

IRF2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.