Overview

Location [1]
16q24.1
Protein [2]
Interferon regulatory factor 8
Synonyms [1]
IRF-8, ICSBP, IMD32A, IMD32B, H-ICSBP, ICSBP1

Interferon regulatory factor 8 (IRF8) is a gene that encodes a protein that functions as a regulatory transcription factor regulates the expression of genes stimulated by type I interferons (IFN-alpha and IFN-beta). Missense mutations, nonsense mutations, silent mutations, nonstop extensions, and frameshift deletions are observed in cancers such as skin cancer, stomach cancer, and upper aerodigestive tract cancer.

IRF8 is altered in 1.50% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, colon adenocarcinoma, B-cell lymphoblastic leukemia/lymphoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

IRF8 GENIE Cases - Top Diseases

The most common alterations in IRF8 are IRF8 Y23H (0.17%), IRF8 T80A (0.12%), IRF8 Loss (0.09%), IRF8 S55A (0.09%), and IRF8 Amplification (0.07%) [3].

IRF8 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.