Overview

Location [1]
13q34
Pathway
PI3K/AKT1/MTOR
Protein [2]
Insulin receptor substrate 2
Synonyms [1]
IRS-2

Insulin receptor substrate 2 (IRS2) is a gene that encodes a protein of the same name that functions in regulating the effects of insulin-like growth factor 1 and insulin by mediating signaling between receptor tyrosine kinases and other associated proteins. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.

IRS2 is altered in 2.76% of all cancers with colorectal adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, melanoma, and uterine corpus neoplasm having the greatest prevalence of alterations [3].

IRS2 GENIE Cases - Top Diseases

The most common alterations in IRS2 are IRS2 Mutation (1.27%), IRS2 Mutation (somatic) (1.27%), IRS2 Amplification (0.35%), IRS2 Loss (0.07%), and IRS2 L20delinsPI (0.02%) [3].

IRS2 GENIE Cases - Top Alterations

Significance of IRS2 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Squamous Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Melanoma +

Gastric Adenocarcinoma +

Colorectal Carcinoma +

Glioblastoma +

Head And Neck Squamous Cell Carcinoma +

Thyroid Gland Carcinoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Pancreatic Carcinoma +

Hepatocellular Carcinoma +

Cancer +

Histiocytic And Dendritic Cell Neoplasm +

Ovarian Carcinoma +

Peritoneal Mesothelioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.