Location [1]
Protein [2]
Insulin receptor substrate 2
Synonyms [1]

Insulin receptor substrate 2 (IRS2) is a gene that encodes a protein of the same name that functions in regulating the effects of insulin-like growth factor 1 and insulin by mediating signaling between receptor tyrosine kinases and other associated proteins. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.

IRS2 is altered in 2.87% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

IRS2 GENIE Cases - Top Diseases

The most common alterations in IRS2 are IRS2 Mutation (2.09%), IRS2 Amplification (0.61%), IRS2 Loss (0.14%), IRS2 A701dup (0.07%), and IRS2 P1036del (0.05%) [3].

IRS2 GENIE Cases - Top Alterations

Significance of IRS2 in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.