Overview

Location [1]
1p32.1
Protein [2]
Transcription factor AP-1
Synonyms [1]
AP-1, AP1, p39, c-Jun, cJUN

Jun proto-oncogene (JUN) is a gene that encodes a protein that functions in the regulation of gene expression. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions and deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

JUN is altered in 0.87% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, dedifferentiated liposarcoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

JUN GENIE Cases - Top Diseases

The most common alterations in JUN are JUN Amplification (0.29%), JUN Loss (0.09%), JUN S37fs (0.03%), JUN E112K (0.03%), and JUN G153fs (0.02%) [3].

JUN GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.