Biomarkers /
KIAA1549
Overview
KIAA1549 is altered in 0.26% of all cancers with pilocytic astrocytoma, low-grade glioma, NOS, astrocytoma, pancreatic adenocarcinoma, and pilomyxoid astrocytoma having the greatest prevalence of alterations [3].
The most common alterations in KIAA1549 are KIAA1549-BRAF Fusion (0.23%), KIAA1549 Fusion (0.20%), KIAA1549 A1509S (0.30%), KIAA1549 A1696V (0.30%), and KIAA1549 A732V (0.30%) [3].
Clinical Trials
Significance of KIAA1549 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.