Location [1]
Protein [2]
UPF0606 protein KIAA1549
Synonyms [1]

KIAA1549 is altered in 0.26% of all cancers with pilocytic astrocytoma, low-grade glioma, NOS, astrocytoma, pancreatic adenocarcinoma, and pilomyxoid astrocytoma having the greatest prevalence of alterations [3].

KIAA1549 GENIE Cases - Top Diseases

The most common alterations in KIAA1549 are KIAA1549-BRAF Fusion (0.23%), KIAA1549 Fusion (0.20%), KIAA1549 A1509S (0.30%), KIAA1549 A1696V (0.30%), and KIAA1549 A732V (0.30%) [3].

KIAA1549 GENIE Cases - Top Alterations

Significance of KIAA1549 in Diseases

Pilocytic Astrocytoma +

Low Grade Glioma +

Glioma +

Neurofibromatosis Type 1 +

Optic Nerve Glioma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.