Overview

Location [1]
3q27.1
Pathway
Immune checkpoints
Protein [2]
Kelch-like protein 6
Synonyms [1]
-

Kelch-like family member 6 (KLHL6) is a gene that encodes a protein that functions in B-lymphocyte antigen receptor signaling. The protein also plays a role in germinal center formation. Missense, nonsense, silent mutations are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

KLHL6 is altered in 1.48% of all cancers with melanoma, lung adenocarcinoma, high grade ovarian serous adenocarcinoma, conventional glioblastoma multiforme, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

KLHL6 GENIE Cases - Top Diseases

The most common alterations in KLHL6 are KLHL6 Amplification (1.38%), KLHL6 G617R (0.11%), KLHL6 S306L (0.24%), KLHL6 V619M (0.37%), and KLHL6 A371T (0.19%) [3].

KLHL6 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.