Overview

Location [1]
15q15.1
Protein [2]
Small kinetochore-associated protein
Synonyms [1]
C15orf23, TRAF4AF1, HSD11, SKAP

Kinetochore-localized astrin/SPAG5 binding protein (KNSTRN; also known as C15orf23) is a gene that encodes a protein involved in chromosome segregation during mitosis. Missense mutations, synonymous mutations, and nonsense mutations are observed in cancers such as skin cancer, stomach cancer, and colon cancer.

KNSTRN is altered in 0.78% of all cancers with cutaneous melanoma, lung adenocarcinoma, melanoma of unknown primary, skin squamous cell carcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

KNSTRN GENIE Cases - Top Diseases

The most common alterations in KNSTRN are KNSTRN Loss (0.17%), KNSTRN S24F (0.15%), KNSTRN Amplification (0.04%), KNSTRN E5K (0.02%), and KNSTRN D23N (0.02%) [3].

KNSTRN GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.