Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
DNA ligase 4
Synonyms [1]

LIG4 is altered in 0.14% of all cancers.

The most common alterations in LIG4 are LIG4 Amplification (0.01%) and LIG4 Loss (0.01%) [3].

LIG4 GENIE Cases - Top Alterations

Significance of LIG4 in Diseases

Melanoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.