Overview

Location [1]
11q13.2
Pathway
Beta-Catenin/WNT signaling
Protein [2]
Low-density lipoprotein receptor-related protein 5
Synonyms [1]
BMND1, EVR4, OPTA1, EVR1, OPS, LRP7, HBM, VBCH2, LRP-5, OPPG, LR3, PCLD4

Low density lipoprotein receptor-related protein 5 (LRP5) is a gene that encodes a transmembrane low-density lipoprotein receptor protein that also functions as a co-receptor with Frizzled family proteins to transduce signals by Wnt proteins. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as cervical cancer, skin cancer, and stomach cancer.

LRP5 is altered in 0.02% of all cancers with prostate adenocarcinoma and sarcoma, NOS having the greatest prevalence of alterations [3].

LRP5 GENIE Cases - Top Diseases

The most common alterations in LRP5 are LRP5-MEN1 Fusion (0.02%) and LRP5-TP53 Fusion (0.04%) [3].

LRP5 GENIE Cases - Top Alterations

Significance of LRP5 in Diseases

Esophageal Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Cervical Squamous Cell Carcinoma +

Colorectal Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Solid Tumor +

Melanoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.