Location [1]
Beta-Catenin/WNT signaling
Protein [2]
Low-density lipoprotein receptor-related protein 6
Synonyms [1]

Low density lipoprotein receptor-related protein 6 (LRP6) is a gene that encodes a transmembrane low-density lipoprotein receptor protein that also functions as a co-receptor with Frizzled family proteins to transduce signals by Wnt proteins. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

LRP6 is altered in 0.01% of all cancers with astrocytoma and cutaneous melanoma having the greatest prevalence of alterations [3].

LRP6 GENIE Cases - Top Diseases

The most common alterations in LRP6 are LRP6 L1436F (3.57%), LRP6 Mutation (3.57%), and LRP6-ETV6 Fusion (0.00%) [3].

LRP6 GENIE Cases - Top Alterations

Significance of LRP6 in Diseases

Esophageal Squamous Cell Carcinoma +

Melanoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Cervical Squamous Cell Carcinoma +

Colorectal Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.