Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Transcription factor MafB
Synonyms [1]

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is a gene that encodes a transcription factor protein that functions in the regulation of lineage-specific hematopoiesis. Fusions, missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, pleural cancer, and stomach cancer.

MAFB is altered in 0.17% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

MAFB GENIE Cases - Top Diseases

The most common alterations in MAFB are MAFB Amplification (0.09%), MAFB S123T (0.06%), MAFB A176T (0.03%), MAFB A177T (0.03%), and MAFB A180E (0.03%) [3].

MAFB GENIE Cases - Top Alterations

Significance of MAFB in Diseases

Multiple Myeloma +

Plasma Cell Leukemia +

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Chronic Lymphocytic Leukemia +

Chronic Myeloid Leukemia +

Hodgkin Lymphoma +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Aplastic Anemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Chronic Myelomonocytic Leukemia +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Lymphoblastic Lymphoma +

Lymphoma +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Myelofibrosis +

Plasmacytoma +

Prolymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Triple-Hit Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.