Location [1]
Protein [2]
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms [1]

MALT1 paracaspase (MALT1) is a gene that encodes a protein that may function in NF-kappaB activation. Fusions, missense and silent mutations are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

MALT1 is altered in 0.92% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

MALT1 GENIE Cases - Top Diseases

The most common alterations in MALT1 are MALT1 Loss (0.31%), MALT1 Amplification (0.11%), MALT1 X126_splice (0.04%), MALT1 X167_splice (0.02%), and MALT1 D471N (0.01%) [3].

MALT1 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of MALT1 in Diseases

Marginal Zone Lymphoma +

Mature B-Cell Lymphoma/Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.