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MAP3K10

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Associated Diseases

Overview

Location [1]
19q13.2
Protein [2]
Mitogen-activated protein kinase kinase kinase 10
Synonyms [1]
MEKK10, MLK2, MST

MAP3K10 is altered in 2.15% of all cancers with breast invasive ductal carcinoma, mixed lobular and ductal breast carcinoma, breast invasive lobular carcinoma, breast neoplasm, and mucinous breast carcinoma having the greatest prevalence of alterations [3].

MAP3K10 GENIE Cases - Top Diseases

The most common alterations in MAP3K10 are MAP3K10 Amplification (1.07%), MAP3K10 V521M (0.08%), MAP3K10 A782_P840del (0.04%), MAP3K10 A884V (0.04%), and MAP3K10 D733Y (0.04%) [3].

MAP3K10 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.