MYC associated factor X (MAX) is a gene that encodes a protein belongs to the basic helix-loop-helix leucine zipper (bHLHZ) transcription factor family. The protein functions as an oncoprotein that is involved in cell proliferation, differentiation, and apoptosis. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
MAX is altered in 0.84% of all cancers with lung adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, gastrointestinal stromal tumor, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in MAX are MAX Mutation (0.59%), MAX R60Q (0.12%), MAX Loss (0.10%), MAX Amplification (0.08%), and MAX H28R (0.03%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.