Overview

Location [1]
Xq13.1
Synonyms [1]
TNRC11, TRAP230, OKS, FGS1, ARC240, MED12S, OHDOX, CAGH45, Kto, OPA1, HOPA

Mediator complex subunit 12 (MED12) is a gene that encodes a protein that is a member of a CDK8 protein complex that binds to a component of the preinitiation complex that functions in protein assembly. The protein encoded by this gene functions in the regulation of transcription. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions and insertions are observed in cancers such as breast cancer, endometrial cancer, and lung cancer.

Significance of MED12 in Diseases

Anaplastic Astrocytoma +

Bladder Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Lymphoma +

Malignant Solid Tumor +

Melanoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.