Location [1]
Protein [2]
Tyrosine-protein kinase Mer
Synonyms [1]
MER, c-mer, Tyro12, c-Eyk, RP38

MERTK is altered in 4.15% of all cancers with endometrial carcinoma, rectal adenocarcinoma, adenocarcinoma of unknown primary, bladder urothelial carcinoma, and cancer of unknown primary, NOS having the greatest prevalence of alterations [3].

MERTK GENIE Cases - Top Diseases

The most common alterations in MERTK are MERTK Mutation (4.15%), MERTK A155T (0.30%), MERTK C361F (2.08%), MERTK E27K (2.08%), and MERTK E926A (0.30%) [3].

MERTK GENIE Cases - Top Alterations

Significance of MERTK in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.