Overview

Location [1]
15q15.1
Protein [2]
MAX gene-associated protein
Synonyms [1]
MAD5, MXD5

MGA is altered in 4.39% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

MGA GENIE Cases - Top Diseases

The most common alterations in MGA are MGA Loss (0.21%), MGA E1249fs (0.08%), MGA R2435W (0.05%), MGA R1818* (0.04%), and MGA R2436H (0.04%) [3].

MGA GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.