Location [1]
Protein [2]
Methylated-DNA--protein-cysteine methyltransferase
Synonyms [1]

MGMT is altered in 0.05% of all cancers with conventional glioblastoma multiforme, melanoma, adenocarcinoma of unknown primary, astrocytoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

MGMT GENIE Cases - Top Diseases

The most common alterations in MGMT are MGMT Mutation (0.46%), MGMT *239S (0.07%), MGMT A82V (0.07%), MGMT E197K (0.07%), and MGMT G162* (0.07%) [3].

MGMT GENIE Cases - Top Alterations

Significance of MGMT in Diseases

Breast Carcinoma +

Glioblastoma +

Colorectal Adenocarcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.