Overview

Location [1]
Xq12
Protein [2]
Moesin
Synonyms [1]
HEL70, IMD50

Moesin (MSN) is a gene that encodes a protein that functions as a cross-linker between the plasma membrane and actin-based cytoskeleton. Fusions, missense mutations, nonsense mutations, silent mutations, nonstop extensions, frameshift insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and peritoneal cancer.

MSN is altered in 0.08% of all cancers with lung adenocarcinoma, dedifferentiated liposarcoma, breast invasive ductal carcinoma, acute myeloid leukemia, and anaplastic ganglioglioma having the greatest prevalence of alterations [3].

MSN GENIE Cases - Top Diseases

The most common alterations in MSN are MSN-ROS1 Fusion (0.10%), MSN-ALK Fusion (0.08%), and MSN-AMER1 Fusion (0.00%) [3].

MSN GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.