Overview

Location [1]
6q23.3
Synonyms [1]
Cmyb, c-myb, efg, c-myb_CDS

V-myb avian myeloblastosis viral oncogene homolog (MYB) is a gene that encodes a transcription factor protein that functions in both transcriptional activation and transcriptional repression. The protein also regulates hematopoiesis and tumorigenesis. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as breast cancer, endometrial cancer, and skin cancer.

Significance of MYB in Diseases

Astrocytic Tumor +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Ganglioglioma +

Low Grade Glioma +

Low-Grade Neuroepithelial Tumor, NOS +

Neuronal And Mixed Neuronal-Glial Tumors +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.