Location [1]
Protein [2]
Transcriptional activator Myb
Synonyms [1]
Cmyb, c-myb_CDS, efg, c-myb

V-myb avian myeloblastosis viral oncogene homolog (MYB) is a gene that encodes a transcription factor protein that functions in both transcriptional activation and transcriptional repression. The protein also regulates hematopoiesis and tumorigenesis. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as breast cancer, endometrial cancer, and skin cancer.

MYB is altered in 0.66% of all cancers with salivary gland adenoid cystic carcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, invasive breast carcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

MYB GENIE Cases - Top Diseases

The most common alterations in MYB are MYB Mutation (0.92%), MYB-NFIB Fusion (0.10%), MYB Amplification (0.19%), MYB-QKI Fusion (0.13%), and MYB Fusion (0.10%) [3].

MYB GENIE Cases - Top Alterations

Significance of MYB in Diseases

Pilomyxoid Astrocytoma +

Diffuse Glioma +

Astrocytic Tumor +

Low Grade Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Gangliocytoma +

Ganglioglioma +

Low-Grade Neuroepithelial Tumor, NOS +

Neuronal And Mixed Neuronal-Glial Tumors +

Pilocytic Astrocytoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.