Overview

Location [1]
1p34.2
Protein [2]
Protein L-Myc
Synonyms [1]
MYCL1, L-Myc, LMYC, bHLHe38

V-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog (MYCL) is a gene that encodes a protein that functions in DNA binding. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as liver cancer, lung cancer, and skin cancer.

MYCL is altered in 0.36% of all cancers with bladder urothelial carcinoma, breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, small cell lung carcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

MYCL GENIE Cases - Top Diseases

The most common alterations in MYCL are MYCL Amplification (0.40%) and MYCL Loss (0.03%) [3].

MYCL GENIE Cases - Top Alterations

Significance of MYCL in Diseases

Medulloblastoma +

Medulloblastoma, Non-WNT/Non-SHH +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Desmoplastic/Nodular Medulloblastoma +

Large Cell/Anaplastic Medulloblastoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Small Cell Lung Carcinoma +

Anaplastic Astrocytoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Atypical Teratoid/Rhabdoid Tumor +

Diffuse Glioma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma +

Ependymoma, RELA Fusion-Positive +

Glioblastoma +

High-Grade Glioma, NOS +

Intracranial Primitive Neuroectodermal Neoplasm +

Malignant Glioma +

Pineoblastoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.