Overview

Location [1]
2p24.3
Synonyms [1]
N-myc, bHLHe37, MODED, NMYC, ODED

The v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) gene encodes a protein located in the nucleus. The protein dimerizes with a co-protein to bind DNA. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Significance of MYCN in Diseases

Neuroblastoma +

Medulloblastoma +

Malignant Solid Tumor +

Medulloblastoma, Non-WNT/Non-SHH +

Desmoplastic Small Round Cell Tumor +

Ependymoma +

Soft Tissue Sarcoma +

Atypical Teratoid/Rhabdoid Tumor +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Desmoplastic/Nodular Medulloblastoma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Large Cell/Anaplastic Medulloblastoma +

Malignant Glioma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Melanoma +

Osteosarcoma +

Alveolar Rhabdomyosarcoma +

Anaplastic Astrocytoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Burkitt Lymphoma +

Central Nervous System Lymphoma +

Central Nervous System Neoplasm +

Childhood Central Nervous System Embryonal Carcinoma +

Choroid Plexus Neoplasm +

Craniopharyngioma +

Diffuse Glioma +

Diffuse Intrinsic Pontine Glioma +

Diffuse Large B-Cell Lymphoma +

Diffuse Midline Glioma, H3 K27M-Mutant +

Double-Hit Lymphoma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma, RELA Fusion-Positive +

Ewing Sarcoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Of Bone +

Fibrosarcoma +

Follicular Lymphoma +

Ganglioneuroblastoma +

Ganglioneuroblastoma, Intermixed +

Ganglioneuroblastoma, Nodular +

Germ Cell Tumor +

Glioblastoma +

Glioma +

High-Grade Glioma, NOS +

Hodgkin Lymphoma +

Intracranial Primitive Neuroectodermal Neoplasm +

Kidney Wilms Tumor +

Leiomyosarcoma +

Liposarcoma +

Lymphoma +

Mantle Cell Lymphoma +

Mature B-Cell Non-Hodgkin Lymphoma +

Meningioma +

NUT Midline Carcinoma Of The Head And Neck +

Neuroectodermal Tumor Of Soft Tissue +

Peripheral T-Cell Lymphoma +

Pineoblastoma +

Retinoblastoma +

Rhabdoid Tumor +

Small Cell Lung Carcinoma +

Spindle Cell Sarcoma +

Synovial Sarcoma +

Undifferentiated Pleomorphic Sarcoma +

Wilms Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.