Overview

Location [1]
17p12-p11.2
Protein [2]
Nuclear receptor corepressor 1
Synonyms [1]
N-CoR, hN-CoR, N-CoR1, TRAC1, PPP1R109

NCOR1 is altered in 3.19% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

NCOR1 GENIE Cases - Top Diseases

The most common alterations in NCOR1 are NCOR1 Amplification (0.32%), NCOR1 Loss (0.24%), NCOR1 R414* (0.02%), NCOR1 E531del (0.01%), and NCOR1 R1326* (0.01%) [3].

NCOR1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.