Location [1]
Protein [2]
Synonyms [1]

Nicastrin (NCSTN) is a gene that encodes a protein that cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein. Missense mutations, synonymous mutations, nonsense mutations, and frameshift mutations are observed in cancers such as stomach cancer, colon cancer, and urinary tract cancer.

Significance of NCSTN in Diseases

Breast Carcinoma +

Cholangiocarcinoma +

Colon Carcinoma +

Lymphoma +

Malignant Solid Tumor +

Soft Tissue Sarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.