Location [1]
Protein [2]
Synonyms [1]

Nicastrin (NCSTN) is a gene that encodes a protein that cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein. Missense mutations, synonymous mutations, nonsense mutations, and frameshift mutations are observed in cancers such as stomach cancer, colon cancer, and urinary tract cancer.

NCSTN is altered in 0.52% of all cancers with colon adenocarcinoma, lung adenocarcinoma, mantle cell lymphoma, acute myeloid leukemia, and mature B-cell neoplasm having the greatest prevalence of alterations [3].

NCSTN GENIE Cases - Top Diseases

The most common alterations in NCSTN are NCSTN Mutation (0.31%), NCSTN Amplification (0.18%), NCSTN Loss (0.09%), NCSTN K190R (0.05%), and NCSTN T400I (0.17%) [3].

NCSTN GENIE Cases - Top Alterations

Significance of NCSTN in Diseases

Breast Carcinoma +

Colon Carcinoma +

Malignant Solid Tumor +

Lymphoma +

Soft Tissue Sarcoma +

Cholangiocarcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.