Biomarkers /

NFKBIE

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Overview

Location [1]
6p21.1
Protein [2]
NF-kappa-B inhibitor epsilon
Synonyms [1]
IKBE

NFKBIE is altered in 1.39% of all cancers with melanoma, colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

NFKBIE GENIE Cases - Top Diseases

The most common alterations in NFKBIE are NFKBIE G34E (0.17%), NFKBIE Y254fs (0.11%), NFKBIE Amplification (0.11%), NFKBIE A89V (0.08%), and NFKBIE G41E (0.06%) [3].

NFKBIE GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.