Location [1]
Protein [2]
Notch 4 intracellular domain
Synonyms [1]

NOTCH4 is altered in 2.89% of all cancers with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

NOTCH4 GENIE Cases - Top Diseases

The most common alterations in NOTCH4 are NOTCH4 Mutation (2.47%), NOTCH4 Amplification (0.11%), NOTCH4 Loss (0.07%), NOTCH4 Fusion (0.04%), and NOTCH4 E1836K (0.02%) [3].

NOTCH4 GENIE Cases - Top Alterations

Significance of NOTCH4 in Diseases

Breast Carcinoma +

Colon Carcinoma +

Malignant Solid Tumor +

Cholangiocarcinoma +

Lymphoma +

Soft Tissue Sarcoma +

Adenoid Cystic Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.