Location [1]
Protein [2]
Notch 4 intracellular domain
Synonyms [1]

NOTCH4 is altered in 2.30% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

NOTCH4 GENIE Cases - Top Diseases

The most common alterations in NOTCH4 are NOTCH4 Mutation (1.59%), NOTCH4 Amplification (0.05%), NOTCH4 G1891Afs*13 (0.02%), NOTCH4 Loss (0.02%), and NOTCH4 E1836K (0.01%) [3].

NOTCH4 GENIE Cases - Top Alterations

Significance of NOTCH4 in Diseases

Colon Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Adenoid Cystic Carcinoma +

Cholangiocarcinoma +

Lymphoma +

Soft Tissue Sarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.