Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
5q31.3
Protein [2]
Glucocorticoid receptor
Synonyms [1]
GCRST, GRL, GCR, GCCR, GR

NR3C1 is altered in 0.62% of all cancers with breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

NR3C1 GENIE Cases - Top Diseases

The most common alteration in NR3C1 is NR3C1 Amplification (0.03%) [3].

NR3C1 GENIE Cases - Top Alterations

Significance of NR3C1 in Diseases

Breast Carcinoma +

Bladder Carcinoma +

Fallopian Tube Carcinoma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Prostate Carcinoma +

Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.