Overview

Location [1]
8p12
Protein [2]
Neuregulin-1
Synonyms [1]
MST131, MSTP131, ARIA, HRGA, GGF, NDF, GGF2, HGL, HRG1, SMDF, NRG1-IT2, HRG

NRG1 is altered in 0.70% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, breast invasive ductal carcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

NRG1 GENIE Cases - Top Diseases

The most common alterations in NRG1 are NRG1 Mutation (2.29%), NRG1 Fusion (0.18%), NRG1 Loss (0.29%), NRG1 Amplification (0.09%), and NRG1 A467V (0.07%) [3].

NRG1 GENIE Cases - Top Alterations

Significance of NRG1 in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Melanoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Malignant Uterine Neoplasm +

Lung Carcinoma +

Bladder Carcinoma +

Gastric Adenocarcinoma +

Colorectal Carcinoma +

Bile Duct Carcinoma +

Head And Neck Carcinoma +

Soft Tissue Sarcoma +

Cervical Carcinoma +

Ovarian Carcinoma +

Bronchogenic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.