Associated Genetic Biomarkers
Nuclear mitotic apparatus protein 1 (NUMA1) is a gene that encodes a protein that functions as a structural component of the nuclear matrix. The protein also interacts with microtubules and helps form and organize the mitotic spindle during cell division. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
NUMA1 is altered in 0.12% of all cancers.
NUMA1 status serves as an inclusion eligibility criteria in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains NUMA1 status as an inclusion criterion, 1 is phase 3 (1 open).
The most frequent alteration to serve as an inclusion eligibility criterion is NUMA1-RARA Fusion .
Significance of NUMA1 in Diseases
Acute Myeloid Leukemia +
NUMA1 is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains NUMA1 status and acute myeloid leukemia as inclusion criteria, 1 is phase 3 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.