Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Nuclear mitotic apparatus protein 1
Synonyms [1]

Nuclear mitotic apparatus protein 1 (NUMA1) is a gene that encodes a protein that functions as a structural component of the nuclear matrix. The protein also interacts with microtubules and helps form and organize the mitotic spindle during cell division. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

NUMA1 is altered in 1.90% of all cancers with non-small cell lung carcinoma, bladder carcinoma, breast carcinoma, esophageal cancer, and malignant glioma having the greatest prevalence of alterations [3].

NUMA1 GENIE Cases - Top Diseases

The most common alterations in NUMA1 are NUMA1 A1075S (0.00%), NUMA1 A1194T (0.00%), NUMA1 A2097T (0.00%), NUMA1 E2002K (0.00%), and NUMA1 E719* (0.00%) [3].

NUMA1 GENIE Cases - Top Alterations

Significance of NUMA1 in Diseases

Acute Myeloid Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.