Overview

Location [1]
16q13
Protein [2]
Nuclear pore complex protein Nup93
Synonyms [1]
NIC96

Nucleoporin 93kDa (NUP93) is a gene that encodes a protein that functions in nuclear pore complex assembly. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

NUP93 is altered in 1.27% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, bladder urothelial carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

NUP93 GENIE Cases - Top Diseases

The most common alterations in NUP93 are NUP93 Loss (0.12%), NUP93 E14K (0.10%), NUP93 Q15* (0.08%), NUP93 Amplification (0.05%), and NUP93 A186V (0.01%) [3].

NUP93 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.