Overview

Location [1]
Xq23
Protein [2]
Serine/threonine-protein kinase PAK 3
Synonyms [1]
PAK-3, MRX30, PAK3beta, beta-PAK, ARA, MRX47, OPHN3, bPAK

The p21 protein (Cdc42/Rac)-activated kinase 3 (PAK3) gene encodes a serine/threonine kinase protein that activates p21 and links Rho GTPases to cytoskeleton reorganization and nuclear signaling processes. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and lung cancer.

PAK3 is altered in 1.18% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, melanoma, and basal cell carcinoma having the greatest prevalence of alterations [3].

PAK3 GENIE Cases - Top Diseases

The most common alterations in PAK3 are PAK3 Mutation (1.11%), PAK3 G108E (0.18%), PAK3 P237Q (0.10%), PAK3 D190E (0.18%), and PAK3 Loss (0.12%) [3].

PAK3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.