Biomarkers /
PBX1
Overview
Pre-B-cell leukemia homeobox 1 (PBX1) is a gene that encodes a nuclear protein that may function in the regulation of osteogenesis and skeletal patterning/programming. A chromosomal translocation resulting in a fusion protein contributes to the development of pre-B-cell acute lymphoblastic leukemia. Fusions, missense mutations, and silent mutations are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.
Clinical Trials
Significance of PBX1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.