Overview

Location [1]
2p13.3
Protein [2]
Poly(rC)-binding protein 1
Synonyms [1]
HNRPX, HNRPE1, hnRNP-E1, HEL-S-85, hnRNP-X

Poly (rC) binding protein 1 (PCBP1) is a gene that encodes a protein that has multiple functions including RNA binding, translational co-activation of poliovirus RNA, translational control of specific mRNAs, and formation of a sequence-specific alpha-globin mRNP complex. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, stomach cancer, and urinary tract cancer.

PCBP1 is altered in 0.44% of all cancers with colon adenocarcinoma, diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, mediastinal large B-cell lymphoma, and acute myeloid leukemia having the greatest prevalence of alterations [3].

PCBP1 GENIE Cases - Top Diseases

The most common alterations in PCBP1 are PCBP1 L100Q (0.33%), PCBP1 Amplification (0.05%), PCBP1 Loss (0.05%), PCBP1 A73D (0.02%), and PCBP1 G292S (0.02%) [3].

PCBP1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.