Associated Genetic Biomarkers
Associated Diseases

Overview

Biomarker-Directed Therapies

Significance of PD-L1 in Diseases

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Breast Carcinoma +

Cervical Carcinoma +

Gastric Carcinoma +

Malignant Esophageal Neoplasm +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Adenocarcinoma +

Melanoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Squamous Cell Lung Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Colorectal Carcinoma +

Hypopharyngeal Squamous Cell Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Renal Cell Carcinoma +

Bladder Carcinoma +

Ovarian Carcinoma +

Small Cell Lung Carcinoma +

Bladder Urothelial Carcinoma +

Esophageal Squamous Cell Carcinoma +

Urethral Urothelial Carcinoma +

Cervical Adenocarcinoma +

Cervical Adenosquamous Carcinoma +

Cervical Squamous Cell Carcinoma +

Clear Cell Renal Cell Carcinoma +

Cutaneous Melanoma +

Hepatocellular Carcinoma +

Invasive Breast Carcinoma +

Merkel Cell Carcinoma +

Pancreatic Adenocarcinoma +

Prostate Carcinoma +

Renal Pelvis Urothelial Carcinoma +

Ureter Urothelial Carcinoma +

Breast Adenocarcinoma +

Cholangiocarcinoma +

Colorectal Adenocarcinoma +

Diffuse Large B-Cell Lymphoma +

Endometrial Carcinoma +

Esophageal Adenocarcinoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Hodgkin Lymphoma +

Infiltrating Renal Pelvis And Ureter Urothelial Carcinoma +

Lung Adenocarcinoma +

Lymphoma +

Mesothelioma +

Pancreatic Ductal Adenocarcinoma +

Primary Peritoneal Carcinoma +

Prostate Adenocarcinoma +

Skin Squamous Cell Carcinoma +

Alveolar Rhabdomyosarcoma +

Alveolar Soft Part Sarcoma +

Ampulla Of Vater Carcinoma +

Appendix Carcinoma +

Atypical Teratoid/Rhabdoid Tumor +

Basal Cell Carcinoma +

Biliary Tract Carcinoma +

Carcinoma Of Unknown Primary +

Childhood Central Nervous System Embryonal Carcinoma +

Classical Hodgkin Lymphoma +

Desmoplastic Small Round Cell Tumor +

Diffuse Intrinsic Pontine Glioma +

Distal Bile Duct Carcinoma +

Embryonal Rhabdomyosarcoma +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Ependymoma +

Esophageal Carcinoma +

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Of Bone +

Follicular Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Infiltrating Bladder Urothelial Carcinoma +

Intrahepatic Cholangiocarcinoma +

Large Cell Lung Carcinoma +

Liver And Intrahepatic Bile Duct Carcinoma +

Malignant Glioma +

Malignant Mesothelioma +

Malignant Pleural Mesothelioma +

Mediastinal Large B-Cell Lymphoma +

Medulloblastoma +

Mucosal Melanoma +

Multiple Myeloma +

Myelodysplastic Syndromes +

Nasopharyngeal Carcinoma +

Neuroblastoma +

Neuroendocrine Tumor +

Non-Hodgkin Lymphoma +

Oropharyngeal Carcinoma +

Ovarian Endometrioid Adenocarcinoma +

Pancreatic Carcinoma +

Peripheral T-Cell Lymphoma, Not Otherwise Specified +

Peritoneal Malignant Mesothelioma +

Pleural Biphasic Mesothelioma +

Pleural Epithelioid Mesothelioma +

Pleural Mesothelioma, Sarcomatoid Type +

Primary Mediastinal B-Cell Lymphoma +

Renal Pelvis And Ureter Urothelial Carcinoma +

Rhabdoid Tumor +

Squamous Cell Carcinoma +

Squamous Cell Carcinoma Of Unknown Primary +

Synovial Sarcoma +

Transitional Cell Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Wilms Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.