Biomarkers /

PDCD1

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Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
2q37.3
Synonyms [1]
hSLE1, hPD-l, SLEB2, PD-1, hPD-1, CD279, PD1

Programmed cell death 1 (PDCD1) is a gene that encodes a cell surface membrane protein that belongs to the immunoglobulin superfamily. The protein functions in the differentiation of pro-B-cells. The protein may also be important for T-cell functioning and the prevention of autoimmune diseases. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Clinical Trials

View Clinical Trials for PDCD1

Significance of PDCD1 in Diseases

Angioimmunoblastic T-Cell Lymphoma +

Follicular T-Cell Lymphoma +

Nodal Peripheral T-Cell Lymphoma With TFH Phenotype +

Peripheral T-Cell Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.