PGR (progesterone receptor, also known as PR) is a gene that encodes the progesterone receptor protein. The progesterone receptor is a steroid receptor that plays a role in pathogenesis of endometrial cancer and breast cancer (PMID: 23303565). Aberrant PR expression occurs in invasive breast cancer (PMID: 15762276; PMID: 11041059) and endometrial cancer (PMID: 20948320; PMID: 19133508).
PGR is altered in 2.24% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in PGR are PGR Mutation (1.73%), PGR Amplification (0.32%), PGR Loss (0.15%), PGR R740* (0.04%), and PGR Fusion (0.03%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.